Pre-Covid, I used to stay down in Beech Grove, just off South Emerson and 465. Room rates were really affordable ($55/night in 2004, if I remember right), the hotel was clean and quiet, the staff great, a 24-hour Wal-Mart practically in the backyard, and a 24-hour Steak & Shake across the street, plus who knows just how many other restaurants within a mile.
And I really enjoyed the drives coming and going -- just a really good time to get the head lined up for either gaming or sleep. (We won't get into trying to go from I-65 (again, if I remember right) across four lanes on traffic on the 465 to the Emerson exit -- in probably less than a mile. Not fun, especially with the poor lighting, sometimes heavy traffic, and that almost-90 degree turn from 65 to 465 at highway speeds. Yeah, made going down to Southport Road a lot more attractive.)
Today, that Steak & Shake and Wal-Mart are closing at 11pm, and that same hotel's asking for $150/night during Gen Con. Yeah, they caught the fever, and, yeah, I'm not going back because of that.
Last year, I stayed at a Red Roof Inn in the northeast area. Staff was great, but the hotel definitely gave a "no-tell motel" vibe. The drive in and back wasn't the most fun either, what with the road construction, and dining, especially late night, was pretty scant within a mile or two. But, for a solo traveler like me, it was affordable and it worked.
Crossing my fingers things'll be better at a different hotel in a different part of town this year.